Serum immunological markers as predictors of effectiveness of antipsychotic therapy in patients with schizophrenia
Klushnik, T.P.; Syriachenko, T.M.; Brusov, O.S.; Sarmanova, Z.V.; Otman, I.N.; Dupin, A.M.; Sokolov, R.E.
Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova 108(1): 31-35
2008
ISSN/ISBN: 1997-7298 PMID: 18427517 Document Number: 622150
Serum immunological parameters - activity of leukocyte elastase (LE) and alpha(1)-proteinase inhibitor (alpha(1)-PI), content of C-reactive protein, von Willebrand factor, interleukin 8 as well as a level of autoantibodies to neuroantigens (nerve growth factor and basic myelin protein) were studied in patients with schizophrenia during their treatment with psychotropic drugs. All parameters studied differed in the groups of patients and controls. However, the pronounced dynamics was found only for LE and alpha(1)-PI activity. After the therapeutic course, the reduction of LE activity accompanied by the increase of alpha(1)-PI activity was observed. The correlation study between the biological parameters during disease exacerbation and therapeutic effectiveness assessed by the PANSS scores revealed that activity of LE and alpha(1)-PI may be considered as a prognostic marker of therapeutic efficacy, i.e. the high enzyme activity at the moment of maximal activity of the process was predictive of good therapeutic response.