Androgen receptor polymorphism in relation to medical conditions characterized by hyper/hypoandrogenism
Ayalon, I.; Ben-Shachar, S.; Eyal, O.; Weintrob, N.
Harefuah 153(6): 334-337; 367
2014
ISSN/ISBN: 0017-7768 PMID: 25095606 Document Number: 674467
An androgen receptor (AR) is a transcription factor consisting of four functional regions. The transactivation region contains a highly polymorphic area characterized by a variable number of CAG trinucleotide repeats encoding a polyglutamine tract. Several in vitro studies demonstrated a negative linear relation between the lengths of CAG repeats and relative AR transactivations. Numerous clinical studies then sought associations between the described polymorphism and clinical parameters of various medical conditions characterized by hyper/hypoandrogenism. In this article, we describe some of those interesting associations. We believe such links should be investigated in any medical condition involving androgens as a key element in its pathogenesis.