Monitoring options and reversal agents for oral anticoagulants
Thorup, S.B.; Husted, S.E.ær.; Vang, M.L.
Ugeskrift for Laeger 176(9)
2014
ISSN/ISBN: 1603-6824 PMID: 25096568 Document Number: 674201
The approval of the oral direct thrombin inhibitor dabigatranetexilat and the oral factor Xa inhibitors rivaroxaban and apixaban as thromboprophylaxis challenges the position of the vitamin K antagonists (VKA). Predictable pharmacodynamics gives the new oral anticoagulants an advantageous profile. Unlike VKAs there is no specific reversal agent available for the new oral anticoagulants. Experience with haemostatic products for the emergency management of critical bleeding caused by these agents is limited.