Serum markers of oxidative stress and endometriosis
Rosa e Silva, J.C.; do Amara, V.F.; Mendonça, J.L.; Rosa e Silva, A.C.J.d.S.á; Nakao, L.S.; Poli Neto, O.B.; Ferriani, R.A.
Clinical and Experimental Obstetrics and Gynecology 41(4): 371-374
2014
ISSN/ISBN: 0390-6663 PMID: 25134276 Document Number: 673519
Bioethicists can advocate for improved communication with family caregivers when a patient is going to be discharged from the hospital. Healthcare providers are often unaware of a family member's inability to provide needed care. Many patients who access "safety-net" public hospitals have worse outcomes of hospitalization, including readmissions. Bioethicists can advocate for more partnerships between hospitals and community-based programs. To assess the changes secondary to chronic inflammation in women with and without pelvic endometriosis by the determination of serum thiols and carbonyls. Sixty-seven women with endometriosis consecutively submitted to laparoscopy and 41 women without endometriosis consecutively submitted to tubal ligation (control group) were selected. Serum levels of total thiols and carbonyls were determined in both groups. Patients with endometriosis had significantly lower thiol levels than controls (342.37 +/- 142.09 microM vs 559.60 +/- 294.05 microM) (p < 0.001), as well as significantly lower carbonyl levels (8.97 +/- 3.76 microM vs 16.40 +/- 9.26 microM) (p < 0.001). Other clinical characteristics were not associated with changes in marker levels. The cutoff point established by the ROC curve was 396.44 microM for the thiols, with 73.1% sensitivity and 80.5% specificity, and 14.9 microM for the carbonyls, with 94% sensitivity and 51.2% specificity. The serum thiol levels revealed an increase in oxidative stress related to the development of pelvic endometriosis.