Influence of the GPX1 gene polymorphism to aerobic capacity and efficiency of glutathione supplementation in athletes
Lifanov, A.D.; Khadyeva, M.N.; Rakhmatullina, L.Sh.; Demenev, S.V.; Khamidullina, G.F.; Chekulaeva, A.M.; Sofronova, E.M.
Rossiiskii Fiziologicheskii Zhurnal Imeni I.M. Sechenova 100(2): 248-255
2014
ISSN/ISBN: 0869-8139 PMID: 25470901 Document Number: 673454
The aim was to investigate compare genotype and allele frequencies of the GPX1 gene Pro198Leu polymorphism in 736 Russian athletes and 564 non-athletic controls. Echocardiography was performed by ultrasound scanner Nemio MX (Toshiba, Japan). Also, we investigated whether glutathione had antioxidant effects in runners. Runners of the experimental group 1 (16 persons) unlike the group 2 (16 persons) had been administered 600 mg of glutathione sodium intramuscularly after trainings daily, during 14 days. The best response to glutathione was presented by the GPX1 Pro allele.