Problems of depressive insomnia
Tarakanova, E.A.; Ivanchuk, É G.; Rostovshchikov, V.V.
Vestnik Rossiiskoi Akademii Meditsinskikh Nauk 2014(7-8): 153-157
2014
ISSN/ISBN: 0869-6047 PMID: 25563018 Document Number: 673188
To evaluate the efficacy and safety of antidepressant agomelatine in relation to the normalization of circadian rhythms in a psychiatric outpatient practice. It was an open label, non-comparative observational study of 32 patients 18-55 years during the eight-week therapy of major depressive episode mild or moderate severity. For statistical analysis the obtained results were used software package Excel 97. On the background of treatment marked improvement in levels of depression and decreased intra-group scores of the indicators of the scale of Leeds. A statistically significant increase in the proportion of responders and remitters is achieved already in the first 2 weeks of therapy. Thus, in the course of the study, it was shown that along with antidepressant effects, agomelatine able to synchronize disturbed circadian rhythms and to correct sleep disorders in patients with depression.