Solid pseudopapillary tumors of the pancreas: clinical and morphological characteristics, specific features of their immunophenotype, and diagnostic problems
Gurevich, L.E.; Kazantseva, I.A.; Sokolova, I.N.; Korsakova, N.A.; Kuzovleva, E.I.; Chistiakova, O.A.; Aver'ianova, I.A.; Egorov, A.V.; Britvin, T.A.; Dolzhikov, A.A.; Egorov, V.I.
Arkhiv Patologii 76(5): 44-54
2014
ISSN/ISBN: 0004-1955 PMID: 25543408 Document Number: 672943
To analyze 60 cases of solid pseudopapillary tumors (SPTs) of the pancreas, to reveal their most characteristic clinical and morphological features, and to study their possible histogenesis. Sixty cases of SPTs of the pancreas underwent clinical, morphological, and immunohistochemical (IHC) examinations; a comparison group consisted of 86 pancreatic tumors of other histogenesis. It has been shown for the first time that SPTs are characterized by the nuclear expression of claudin 3 and the cytoplasmic expression of claudin 7. It has been also ascertained that the aberrant perinuclear (dot-like) expression of CD99 is a unique feature of these tumors. SPTs of the pancreas are distinguished by a diversity of clinical manifestations and morphological features, but have a unique immunophenotype, which can differentiate them from other types of pancreatic tumors.
Document emailed within 1 workday
