Cellular adhesion signal transduction network of tumor necrosis factor-alpha induced hepatocellular carcinoma cells
Zheng, Y.; Du, S.; Xu, H.; Xu, Y.; Zhao, H.; Chi, T.; Lu, X.; Sang, X.; Mao, Y.
Zhonghua Yi Xue Za Zhi 94(42): 3345-3348
2014
ISSN/ISBN: 0376-2491 PMID: 25622637 Document Number: 672848
To systemically explore the cellular adhesion signal transduction network of tumor necrosis factor-alpha (TNF-α)-induced hepatocellular carcinoma cells with bioinformatics tools. Published microarray dataset of TNF-α-induced HepG2, human transcription factor database HTRI and human protein-protein interaction database HPRD were used to construct and analyze the signal transduction network. In the signal transduction network, MYC and SP1 were the key nodes of signaling transduction. Several genes from the network were closely related with cellular adhesion.Epidermal growth factor receptor (EGFR) is a possible key gene of effectively regulating cellular adhesion during the induction of TNF-α. EGFR is a possible key gene for TNF-α-induced metastasis of hepatocellular carcinoma.