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Effect of ovariectomy on GLUT4 mRNA levels in adipose and muscle tissues in females of mice C57BL/6J-Agouti Yellow

Iakovleva, T.V.; Makarova, E.N.; Bazhan, N.M.

Rossiiskii Fiziologicheskii Zhurnal Imeni I.M. Sechenova 100(5): 602-612

2014

ISSN/ISBN: 0869-8139
PMID: 25669099
Document Number: 672723
Mutation Yellow at the agouti locus in mice (AY/a-mice) causes the increase of food intake and development of obesity and type 2 diabetes. In AY/a-females the disturbances of glucose and fat metabolisms occur after puberty. Previously we demonstrated that in AY/a-females regulation of blood glucose levels by estradiol was impaired. To investigate the mechanisms of estradiol regulatory action disturbance we determined the effects of ovariectomy and estradiol treatment on mRNA GLUT4 levels in adipose tissue and muscles in AY/a-females. C57BL/6J females, not carrying the Yellow mutation at the agouti locus (a/a-mice), were used as a control. The data suggest that one of the reasons for violations of estradiol regulation of glucose metabolism in AY/a-females is decreasing GLUT4 gene transcription activity in muscle tissue.

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