Botulinum toxin type a (dysport) in the complex rehabilitation of children with spastic forms of cerebral palsy
Zmanovskaia, V.A.; Levitina, E.V.; Popkov, D.A.; Butorina, M.N.; Pavlova, O.L.
Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova 114(7): 33-36
2014
ISSN/ISBN: 1997-7298 PMID: 25176264 Document Number: 672578
To analyze the efficacy of repeated use of dysport in children with spastic forms of cerebral palsy (CP). Forty-five children with CP (main group) received 8 consecutive injections of dysport in the complex treatment. A comparison group consisted of 41 children with CP who received the same complex treatment but without dysport. Disport was used intramuscular in mean dose 26±4 u/kg. A significant decrease of the muscle tone was observed after each following injection of dysport. The muscle tone did not return to baseline 24 weeks after each following injection and significantly differed after the first 4 injections. After 8 repeated courses of botulinotherapy, a number of children needed the operative treatment, were significantly greater in the comparison group (71% vs 47%, p=0,041).