Terpenoids and sterols from Ricinus communis and their activities against diabetes
Li, S.-H.; Deng, Q.; Zhu, L.; Lai, C.-H.; Wang, H.-S.; Tan, Q.-G.
Zhongguo Zhong Yao Za Zhi 39(3): 448-452
2014
ISSN/ISBN: 1001-5302 PMID: 24946546 Document Number: 672539
Seven terpenoids and three sterols were isolated from the methanol extracts of the aerial parts of Ricinus communis by chromatography methods and their structures were identified by spectra analysis as ficusic acid( 1), phytol(2), callyspinol(3) , lupeol(4), 30-norlupan-3beta-ol-20-one(5) , lup-20(29)-en-3beta,15alpha-diol(6) , acetylaleuritolic acid( 7), stigmast4-en-3-one(8) , stig-mast-4-en-6beta-ol-3-one(9) , and stigmast4-en-3,6-dione(10). Compounds 1-3 and 5-10 were obtained from this species for the first time and 5 and 6 showed significant inhibitive activity and good selectivity against 11beta-HSD of mouse and human in vitro. [Key words] Ricinus communis; terpenoids; sterols; 11beta-HSD