Comparative characteristics of genetic aberrations in glioblastomas in children and adults
Ryzhova, M.V.; Shishkina, L.V.; Zheludkova, O.G.; Golanov, A.V.; Gorelyshev, S.K.; Pitskhelauri, D.I.; Bekiashev, A.Kh.; Kobiakov, G.L.; Absaliamova, O.V.; Sycheva, R.V.; Korshunov, A.G.
Zhurnal Voprosy Neirokhirurgii Imeni N. N. Burdenko 78(2): 3
2014
ISSN/ISBN: 0042-8817 PMID: 25033601 Document Number: 672276
Glioblastomas in children and adults are a heterogeneous group of tumors that can be divided into at least three different subgroups: pediatric glioblastomas, IDH1-mutant glioblastomas in adults (the most favorable prognostic subtype), and IDH1-wild type glioblastomas in adults. According to the frequency of detected cytogenetic aberrations (amplification of the MYC/MYCN, EGFR and PDGRFA oncogenes, homozygous deletion of the CDKN2A gene, and deletion of the PTEN gene), pediatric glioblastomas bear analogy to the subgroup of IDH1-mutant glioblastomas in adults.