Antisense oligodeoxynucleotide therapy for castration-resistant prostate cancer
Miyake, H.; Fujisawa, M.
Nihon Rinsho. Japanese Journal of Clinical Medicine 72(12): 2121-2125
2014
ISSN/ISBN: 0047-1852 PMID: 25518344 Document Number: 671679
Because of recent advances in the field of nucleic-acid chemistry, antisense oligodeoxynucleotide (AS ODN) technology can offer an attractive strategy to specifically inhibit expression of target genes causing a wide variety of diseases, including cancers. In prostate cancer (PC), several genes, involved in the acquisition of castration-resistant (CR) phenotype, have been identified, some of which, such as clusterin and heat shock protein 27, are intensively investigated as optimal targets for AS ODN therapy. In this review, we attempted to summarize the progress in the novel therapeutic strategy using AS ODN against CRPC, and to discuss the data of the recently completed and currently conducting clinical trials using AS ODNs as well as the future prospects of this therapy for treating CRPC.