Pseudomonas as trespassers in diabetic foot infections: More questions and fewer answers
Najjad, M.Kazim.Rahim.; Idrees, Z.; Zamir, M.; Zeeshan, S.; Shah, S.Amir.Ali.
Jpma. Journal of the Pakistan Medical Association 64(12 Suppl. 2): S112-S115
2014
ISSN/ISBN: 0030-9982 PMID: 25989756 Document Number: 671482
To assess microbiological isolates from diabetic foot ulcers presented at a tertiary care teaching hospital. The prospective observational study was conducted at department of Orthopaedics, Liaquat National Hospital Karachi, from January 2009 to October 2011, and comprised patients with diabetic foot ulcers (Wagner grading 1-4). Grade 0 and 5 were excluded. Wound swabs or tissue biopsies were taken before the induction of antibiotic prophylaxis according to the standard aseptic protocols. SPSS 16 was used for statistical analysis. Of the 250 patients in the study, 151(60.4%) were male with an overall mean age of the subjects of 46±8.1 years. Mean duration of diabetes was 14±6.7 years. Based on Wagner's grading, 90(36%) patients had grade 1, 58(23.2%) grade 2, 97(38.8%) grade 3, and 5(2%) grade 4. The most common isolates were polymicrobial in 90(36%) patients and pseudomonas aeruginosa in 87(34.8%). Resistance antibiogram for pseudomonas aeruginosa showed sensitivity against Imipenem, Aztreonam, Ceftazidime, Ciprofloxacin and Gentamicin. The isolation of pseudomonas aeruginosa gives an idea about the recent microbial spectra from our region and should prompt the need for multi-centre studies from South Asia to devise treatment guidelines for this part of the world.