TIR-domain-containing adaptor protein gene TIRAP S180L polymorphism is not increased in Behçet's disease patients in two ethnic cohorts
Turunc, G.; Coskun, D.; Alibaz-Oner, F.; Coit, P.; Duzgun, N.; Alpsoy, E.; Yentur, S.P.; Salvarani, C.; Casali, B.; Kötter, I.; Ergun, T.; Direskeneli, H.; Sawalha, A.H.; Saruhan-Direskeneli, G.
Clinical and Experimental Rheumatology 31(3 Suppl 77: 54-56
2013
ISSN/ISBN: 0392-856X PMID: 24064014 Document Number: 670879
The single nucleotide polymorphism (SNP) of TIRAP (Serine 180 leucine, S180L) that is shown to be associated with Behçet's disease (BD) in a European-derived cohort, but not in Middle Eastern patients is investigated in two other populations. Two cohorts of BD patients and controls from Turkey (n=797) and Italy (n=633) were genotyped by sequence specific primer-polymerase chain reaction (SSP-PCR) or TaqMan q-PCR assays. Genotype and allele frequencies in TIRAP S180L (rs8177374) were not different between BD patients and controls in either ethnicity. Furthermore, a meta-analysis between the Turkish and the Italian BD cohorts did not reveal an association between this non-synonymous SNP in TIRAP and BD (meta-analysis OR=0.94, meta-analysis p=0.61, Q statistic heterogeneity p=0.11). TIRAP S180L gene polymorphism, which was previously shown to be associated with BD in a Caucasian population, has been replicated in either Turkish or Italian population in our study.