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Effect of opioid receptor blockade on antibody response and proliferative response under stress conditions

Geĭn, S.V.; Sharav'eva, I.L.

Eksperimental'naia i Klinicheskaia Farmakologiia 76(1): 30-34

2013

ISSN/ISBN: 0869-2092
PMID: 23461013
Document Number: 670773
It is established that rotation and immobilization stress produces bidirectional effect on AFC number in spleen and on proliferative response of splenocytes. The rotation stress results in augmentation of AFC formation and promotion of spontaneous proliferative activity of splenocytes. The micro-opioid receptor blockade with naloxone, but not delta-receptor blockade with naltrindole, abolished the effects of rotation. In contrast, the immobilization stress caused the suppression of the parameters of humoral immune response and lowered spontaneous and induced proliferative activity of splenocytes. The opioid receptor blockade with naloxone was found to level the suppressive effects of immobilization, while naltrindole exhibited a less pronounced effect. Both variants of stress demonstrated the involvement of opioid system in regulation of AFC number during induction of the immune response.

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