Familial adenomatous polyposis
Bülow, S.
Ugeskrift for Laeger 175(19): 1335-1339
2013
ISSN/ISBN: 1603-6824 PMID: 23663370 Document Number: 670691
Familial adenomatous polyposis (FAP) is an autosomally dominant disease characterized by early development of up to thousands of colorectal adenomas and colorectal carcinoma in untreated patients. Extra-colonic manifestations include duodenal adenomatosis and desmoid development. Due to identification of gene carriers by DNA analysis or endoscopy the prognosis is good after early colectomy, but life-long surveillance of the rectum and the duodenum is necessary. The Danish Polyposis Register coordinates prophylactic examination and treatment in the families, and serves as basis for research.