A case of sclerosing angiomatoid nodular transformation of the spleen
Giorlandino, A.; Caltabiano, R.; Lanzafame, S.
Pathologica 105(3): 94-97
2013
ISSN/ISBN: 0031-2983 PMID: 24047036 Document Number: 669751
Sclerosing angiomatoid nodular transformation of the spleen is a rare benign vascular lesion with extensive sclerosis and unknown aetiology. Although its pathogenesis is not clear, it has been postulated that it may represent a peculiar hamartomatous transformation of red pulp in response to an exaggerated non-neoplastic stromal proliferation. However, it is unclear whether SANT is the end stage of a variety of benign splenic conditions including inflammatory pseudotumour, hamartoma or hematoma. Considering that the lesion is benign, splenectomy is curative. We report a new case of SANT, discussing differential diagnosis, immunohistochemical profile and pathogenesis.