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p-p70S6K (Thr 389) Expression in nodular sclerosing hodgkin's disease as evidence for receptor tyrosine kinase signaling

Brown, R.E.; Kamal, N.R.

Annals of Clinical and Laboratory Science 35(4): 413-414

2005

ISSN/ISBN: 0091-7370
PMID: 16254257
Document Number: 590906
Platelet - derived growth factor receptor - alpha (PDGFR-alpha) expression in the Hodgkin/Reed Sternberg cells of nodular sclerosing Hodgkin's disease has been demonstrated in 2 studies. Additional receptor tyrosine kinases have also now been documented. This communication reports the correlative expression in nodular sclerosing Hodgkin's disease of activated ( phosphorylated) p70S6K, one of the putative downstream effectors common to receptor tyrosine kinase signaling.

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