Immunosuppressive effect of bone marrow MSC transplantation in patients with ulcerative colitis with six kinds of one family autoantibodies with cross-relationship between each other
Sagynbaeva, V.É; Lazebnik, L.B.
Eksperimental'naia i Klinicheskaia Gastroenterologiia 9: 34-39
2013
ISSN/ISBN: 1682-8658 PMID: 24933963 Document Number: 669412
The 6 types of cross-linked autobodies of one family where identified during relapsing course of Ulcerativ Colities (UC) acompanied with deterioration of clinical and endoscopic activity and increasing rate of acut inflammatory phase (CRP, number of leukocytes and erythrocyte sedimentation rate) of the disease. On the background of transplantation of mesenchymal bone marrow stromal cells (BM MSC), and despit the identification of six types of autoantibodies to antigens of neutrophils, was observed moderate activity of UC and low concentration of autoantibodies than in immunosuppressive therapy without BM MSC transplantation. Discovered anti-inflammatory effect of BM MSCs transplantation in UC may be explained by the systemic influence of immunosuppressive effect: it is known that the BM MSCs inhibit dendritic cells, T-and B-lymphocytes participating in the immune response, activate regulatory T-cells, which produce antinflammatory cytokines, IL-10 and TGF-1beta, which suppress the inflammatory process.