Evaluation the effectiveness of radiation therapy high-grade gliomas based on the model of TDF (time-dose fractionation)
Izmaĭlov, T.R.; Pan'shin, G.A.; Misliukov, S.M.; Datsenko, P.V.
Voprosy Onkologii 59(5): 629-635
2013
ISSN/ISBN: 0507-3758 PMID: 24260893 Document Number: 669057
There were showed the possibility of using the model of TDF, through which it was possible to take into account the selection of fractionation of radiation for high-grade gliomas and to judge the effectiveness of treatment. Currently, the basis of adjuvant radiation therapy in patients with primary high-grade gliomas is the use of the traditional mode of fractionation dose of radiation from a single focal dose of 2 Gy up to a total focal dose of 60 Gy to the tumor (bed of the removed residual tumor) in Grade 4 and Grade 3 - 54 Gy. In patients who underwent radiotherapy using a single focal dose of 3 Gy, overall survival rate was higher as compared to the group of patients, which was carried out using radiotherapy small dose fractionation.