Effectiveness of dose-intensive polychemotherapy with autologous hemopoietic cell transplantation for high-grade non-Hodgkin lymphoma
Alekseeva, I.A.; Zaritskiĭ, A.I.; Medvedeva, N.V.; Mikhaĭlova, N.B.; Zubarovskaia, L.S.; Afanas'ev, B.V.
Voprosy Onkologii 49(1): 66-70
2003
ISSN/ISBN: 0507-3758 PMID: 12715373 Document Number: 558317
The study included 29 patients with high-grade non-Hodgkin's lymphoma. Nine patients (group 1) received 6-8 cycles of CHOP, another 20-6 cycles of CHOP and Dexa-BEAM followed by autologous hemopoietic cell transplantation with CBV or BEAM conditioning regimen (bone marrow or peripheral stem cells) (group 2). The groups were comparable as far as gender and age are concerned. Overall 5-year survival was in 24.1 and 71.4%, respectively. Double CHOP-Dexa-BEAM plus autologous hemopoietic cell transplantation proved superior to standard CHOP-therapy.
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