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Multicyclic dose-intensive chemotherapy supported by autologous blood progenitor cell transplantation for relapsed small cell lung cancer

Fujimoto, N.; Ueoka, H.; Kiura, K.; Tabata, M.; Bessho, A.; Takata, I.; Sunami, K.; Hiramatsu, Y.; Ikeda, K.; Tanimoto, M.; Harada, M.

Anticancer Research 23(5b): 4229-4232

2003

ISSN/ISBN: 0250-7005
PMID: 14666630
Document Number: 552726
We report two cases with small cell lung cancer (SCLC) receiving multicyclic dose-intensified chemotherapy (DI-CT) supported by autologous blood progenitor cell transplantation (ABPCT). Both cases were initially treated with cisplatin (CDDP), etoposide (ETP) and concurrent thoracic irradiation, however they had recurrent disease within a year. After receiving conventional chemotherapy, they underwent multicyclic DI-CT consisting of CDDP, ETP and ifosfamide supported by G-CSF and ABPCT. Definite regression of the tumors was observed. Severe neutropenia and thrombocytopenia were encountered but they were reversible and no life-threatening complications were experienced. These results suggest the feasibility and effectiveness of multicyclic DI-CT and the usefulness of ABPCT as a treatment option for relapsed SCLC.

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