The early diagnostic of chorionic -amnionitic and intrauterine infection on content of nitrite and non-tiolate nitrosocompounds in plasma under premature discharge of amniotic fluid
Titov, V.I.; Osipov, A.N.; Balitskiĭ, S.P.; Shalina, P.I.
Klinicheskaia Laboratornaia Diagnostika 12: 7-10
2013
ISSN/ISBN: 0869-2084 PMID: 24757857 Document Number: 665213
The article deals with the results of examination of 33 pregnant women with premature discharge of amniotic fluid with purpose to choose an optimal criterion of diagnostic of intrauterine infection. In blood plasma of all female patients the increased, from 0.5 to 2.5 mkmol/l, total content of nitrite and non-tiolate nitrosocompounds non-containing iron (NO2+RNO). In case of pregnant women without intrauterine infection the content of nitrite and netiolate nitrosocompounds did not exceed 0.1 mkmol/l as in all other subjects without inflammatory diseases. The antibacterial and anti-inflammatory therapy applied to female patients with premature discharge of amniotic fluid resulted in lowering of concentration of NO2+RNO up to 0.1 mmol/l and even lower. The study results permit to suppose that concentration of NO2+RNO in plasma is one of sensitive indicators of presence of inflammatory processes concomitant to premature discharge of amniotic fluid which by its sensitivity and specificity is superior to such indicators as number of leucocytes, ESR and concentration of C-reactive protein.