Anti-N-methyl-D-aspartic acid receptor encephalitis: clinical analysis of 7 cases
Song, L.; Liu, A.-h.
Zhonghua Yi Xue Za Zhi 93(31): 2508-2510
2013
ISSN/ISBN: 0376-2491 PMID: 24300278 Document Number: 664350
To summarize the clinical manifestations, immunotherapeutic response and prognosis of anti-N-methyl-D-aspartic acid (NMDA) receptor encephalitis. We analyzed the clinical features, tumor markers, serum/cerebrospinal fluid (CSF) antibodies of seven cases with anti-NMDA receptor encephalitis. And the prognosis of different treatments was observed. Seven patients presented with significant psychiatric symptoms, memory loss, epilepsy, movement disorders and decrease consciousness. And some patients required assisted ventilation because of dysautonomia. All electroencephalography showed slow wave activity without epileptic form discharges. Magnetic resonance imaging was normal or showed T2W and Flair-phase high signal in limbic system, cortex, thalamus. And CSF and serum anti-NMDA receptor antibodies were positive (n = 6). Anti-NMDA receptor encephalitis is a kind of fatal but treatable condition. And timely diagnosis and treatment may yield a favorable prognosis.