Liver stiffness in animals with glutamate-induced obesity (according to shear wave ultrasound elastography)
Kobyliak, N.M.; Dynnyk, O.B.; Mykhal'chyshyn, H.P.; Bodnar, P.M.
Likars'ka Sprava 3: 85-89
2013
ISSN/ISBN: 1019-5297 PMID: 25016754 Document Number: 664288
We studied changes of liver stiffness measured by SWE in animals with glutamate-induced obesity (GIO). We noted significant increase of LS on 63.6% compared to intact rats (P < 0.001). Histologically confirmed non-alcoholic steatosis diagnosed in 93.3% of animals with obesity. The AUROC of SWE for in animals with GIO was 0.983 (95% CI 0.955-0.999; P < 0.001). The optimal LS cutoff point for the prediction of steatosis were > 6.25 kPa, with sensitivity, specificity, PPV and NPV 86.6; 100; 100 and 93.7% respectively.