Top Abstract Purchase Related
Home
>
Node
>
Subnode

Acridine: a versatile heterocyclic nucleus

Kumar, R.; Kaur, M.; Kumari, M.

Acta Poloniae Pharmaceutica 69(1): 3-9

2012

ISSN/ISBN: 0001-6837
PMID: 22574501
Document Number: 663636
Acridine is a heterocyclic nucleus. It plays an important role in various medicines. A number of therapeutic agents are based on acridine nucleus such as quinacrine (antimalarial), acriflavine and proflavine (antiseptics), ethacridine (abortifacient), amsacrine and nitracine (anticancer), and tacrine. Acridine is obtained from high boiling fraction of coal tar. It is also obtained in nature from plant and marine sources. Acridine undergoes a number of reactions such as nucleophilic addition, electrophilic substitution, oxidation, reduction, reductive alkylation and photoalkylation. The present review article summarizes the synthesis, reaction, literature review and pharmaceutical importance of acridine.

Document emailed within 1 workday
Secure & encrypted payments

Bontemps-Gracz, M.M.; Kupiec, A.; Antonini, I.; Borowski, E. 2002: The ability to overcome multidrug resistance of tumor cell lines by novel acridine cytostatics with condensed heterocyclic rings Acta Biochimica Polonica 49(1): 87-92
Mrozek, A.; Karolak-Wojciechowska, J.; Amiel, P.; Barbe, J. 2000: Quantitative analysis of structure-activity relationship in the acridine series. Part 2: Antitumor 9-thiadiazolo-acridine derivatives Acta Poloniae Pharmaceutica 57(6): 425-430
Vel'iaminov, I.B. 1970: Cytologic diagnosis of stomach cancer by the fluorescent method using acridine orange and ethyl-acridine orange fluorochrome Sovetskaia Meditsina 33(8): 82-86
Zhang, J.D.; Yang, X.L. 1999: Projections from subnucleus oralis of the spinal trigeminal nucleus to contralateral thalamus via the relay of juxtatrigeminal nucleus and dorsomedial part of the principal sensory trigeminal nucleus in the rat Journal für Hirnforschung 39(3): 301-310
Bosco, G.; Casabona, A.; Giaquinta, G.; Maci, T.; Valle, M.S.; Perciavalle, V. 2000: C-Fos expression in the basilar pontine nuclei and reticulotegmental nucleus of the rat following lateral cerebellar nucleus stimulation Archives Italiennes de Biologie 138(3): 229-240
Casanova, C.; Molotchnikoff, S. 1986: Changes in the activity of cells in the lateral geniculate nucleus by stimulation of the abducens nucleus area in rabbits Journal de Physiologie 81(1): 7-13
Le-Tkhi-Kuk 1973: Retrograde degeneration of the cells of the oculomotor nucleus (nucleus oculomotorius) following unilateral enucleation of the eye (experimental study) Zhurnal Nevropatologii i Psikhiatrii Imeni S.S. Korsakova 73(1): 50-53
Sturrock, R.R. 1989: A quantitative histological study of the anterodorsal thalamic nucleus and the lateral mammillary nucleus of ageing mice Journal für Hirnforschung 30(2): 191-195
Schneider, B.; Beck, M. 1974: Karyometric analysis of the supraoptic nucleus and the paraventricular nucleus before and after milking the cow Zeitschrift für Mikroskopisch-Anatomische Forschung 88(4): 713-725
Makulkin, R.F.; Novytskyĭ, S.A.; Korniienko, T.V. 1994: Effect of entopeduncular nucleus and reticular part of substantia nigra on the antiepileptic activity of the caudate nucleus in the neocortex Fiziolohichnyi Zhurnal 40(2): 3-9
Yin, Q.H.; Mao, J.R.; Guo, S.Y. 1988: Changes of reactions of neurones in dorsal raphe nucleus and locus coeruleus to electroacupuncture by hypothalamic arcuate nucleus stimulation Functional Neurology 3(3): 263-273
Zhu, B.; Liu, X. 1984: Effects of injection of morphine into the head of the caudate nucleus on activities of neurons of the nucleus raphe magnus in rats Zhongguo Yao Li Xue Bao 5(4): 228-231
Wong, C.L.; Chan, Y.S.; Cheung, Y.M.; Hwang, J.C.; Poon, P.W.; Wong, T.M. 1986: Effects of superfusion of morphine and enkephalins on the activity of single units in the spinal trigeminal nucleus and cuneate nucleus of cat Methods and Findings in Experimental and Clinical Pharmacology 8(6): 351-355
Ule, G. 1983: 2 notable aspects of the hypothalamic control of sexual functions. Feedback effect in the infundibular nucleus--hypertrophy of the subventricular nucleus Der Nervenarzt 54(12): 624-627
Milcu, S.M.; Apostol, G.; Ghiea, D. 1979: Changes in the bioelectric activity of the lateral septal nucleus, dorsal hippocampus and medial habenular nucleus after administration of the pineal peptide extract "crinofizin" Endocrinologie 17(2): 103-108
Trulson, M.E.; Preussler, D.W.; Trulson, V.M. 1984: Differential effects of hallucinogenic drugs on the activity of serotonin-containing neurons in the nucleus centralis superior and nucleus raphe pallidus in freely moving cats Journal of Pharmacology and Experimental Therapeutics 228(1): 94-102
Brauer, E. 1984: Karyovolumetric reactions of large cell neurosecretory nuclear regions, supraoptic nucleus and paraventricular nucleus, in swine and calves and their possible relation to sexual function Archiv für Experimentelle Veterinarmedizin 38(1): 115-119
Rickards, D.A. 1976: The versatile cast saw Veterinary Medicine-Small Animal Clinician 71(12): 1701-1703
Suzuki, H. 1978: Electron microscopic study on the changes of the cerebellar hemisphere cortex and lateral nucleus (dentate nucleus) of adult rats after electric convulsions--changes of astrocytes and purkinje cell perikarya and distal parts of their axons Seishin Shinkeigaku Zasshi 80(3): 105-119
Zhong-Wei, C.; Meyer, V.E.; Beasley, R.W. 1981: The versatile second toe microvascular transfer Orthopedic Clinics of North America 12(4): 827-834