Clinical efficacies and safety of HAG regimen for patients with high-risk myelodysplastic syndromes: a multicentre study
Liu, H.; He, G.-s.; Wu, D.-p.; Sun, A.-n.; Shao, Z.-h.; Qian, S.-x.; Xiao, Z.-j.; Ma, J.; Wang, S.-y.; Xu, X.-p.; Liu, T.; Jin, J.; Chen, Z.-c.; Fang, M.-y.; Chen, B.-a.; Xu, L.-p.; Shen, Z.-x.; Ruan, C.-g.
Zhonghua Yi Xue Za Zhi 92(10): 689-691
2012
ISSN/ISBN: 0376-2491 PMID: 22781297 Document Number: 663233
To evaluate the efficacies and toxicity of HAG (HHT + Ara-C + G-CSF) regimen in patients with high-risk myelodysplastic syndromes (MDS). A total of 97 patients with high-risk MDS received HAG regimen as the induction therapy. The complete remission (CR) rate of all the patients was 52.3% (45/86). The overall response (OR) rate was 66.3% (57/86). The early mortality rate was 9.3% (9/97). There was no significant difference in CR rate and OR rate between the patients aged ≥ 60 and those < 60. The OR rate was 29/34, 9/12 and 6/13 in patients with favorable karyotype, intermediate karyotype and unfavorable karyotype respectively. The OR rate was higher in patients with favorable karyotype than those with unfavorable karyotype (P = 0.038). The major adverse effect was infection. HAG regimen provides higher CR rate and OR rate for patients with high-risk MDS.