3beta-Hydroxysteroid dehydrogenase in ependimocytes of brain lateral ventricle lining and vascular plexus villi in rats of different age
Ryzhavskiĭ, B.I.; Zadvornaia, O.V.
Morfologiia 142(5): 26-29
2012
ISSN/ISBN: 1026-3543 PMID: 23330433 Document Number: 663180
Using the histochemical method, the activity of 3beta-hydroxysteroid dehydrogenase (HSDH) was studied in the brain of laboratory male albino rats of different age groups: 5-6 days (n = 6), 45-50 days (n = 12), and 6 months (n = 15). The quantitative assessment of reaction intensity was performed with the cytospectrophotometer. The results obtained indicate that the ependimocytes lining the brain lateral ventricles and covering the villi of their vascular plexuses are characterized by the presence of HSDH activity typical to that of steroid-producing cells. In this regard ependimocytes may be attributed to the cells that can produce neurosteroids. It was established that HSDH activity in ependimocytes was minimal in the early postnatal period and considerably increased by the prepuberty period, remaining at this level in adult animals.