The experimental search of immunological criteria for identifying stages of development of chronic fluoride intoxication
Mikhaĭlova, N.N.; Kazitskaia, A.S.; Gorokhova, L.G.; Zhukova, A.G.
Meditsina Truda i Promyshlennaia Ekologiia 11: 32-37
2012
ISSN/ISBN: 1026-9428 PMID: 23479958 Document Number: 661735
The experiment has shown the staging of the development of immune response to the chronic fluoride intoxication. Diagnostic criteria of the initial compensation stage are: leukocytosis against the background of reduced number of lymphocytes and increased one of monocytes; high levels of ceruloplasmin in blood plasma, a progressive increase in TNFalpha and cytokine IL-10. At the decompensation stage there are: leukocytosis with increased number of neutrophils; low levels of ceruloplasmin and the cytokines IL-1beta, IL-4 and the high level of TNFalpha, IL-6, IL-10. At the stage of exhaustion there are: leukopenia against the background of lymphocytosis, a high level of Hp, the low values of the level of IgM, IgG.