The effect of various fluoride compounds on the development of experimental root surface caries in hamsters
de Oliveira Cordeiro, J.G.
Bulletin of Tokyo Medical and Dental University 42(3): 105-116
1995
ISSN/ISBN: 0040-8921 PMID: 8556785 Document Number: 453930
The aim of this investigation was to evaluate the effect of topical applications of various fluoride compounds on the development of root surface caries in hamsters. Male golden hamsters (n=115) were divided into 7 groups and were given a caries-promoting diet. Six groups were infected with Actinomyces viscosus ATCC 15987; and to 5 infected groups, distilled water (DW) and solutions containing 500 ppmF of acidulated-phosphate fluoride (APF), stannous fluoride (SnF-2), copper fluoride (CuF-2), and titanium tetrafluoride (TiF-4) were applied topically to the first mandibular molars once daily, 7 days a week, over a 24-week period. A grid method was used to assess the periodontal changes and root surface caries on the first molars. Plaque accumulation was reduced most by SnF-2; and alveolar bone loss was more reduced by SnF-2 and CuF-2. Root surface caries was significantly prevented in all fluoride groups when compared to an infected control group; and TiF-4 was the most effective fluoride compound followed by SnF-2, CuF-2, and APF. Root caries scores of the TiF-2 and SnF-2, groups were significantly lower than those of the DW group. It was concluded that all fluoride compounds tested may prevent the development of root surface caries in hamsters.