Changes of the state of rat kidneys under guerin carcinoma development and use of cytostatics
Babiĭ, S.O.; Loskutova, T.O.; Shtemenko, N.I.
Ukrains'kyi Biokhimichnyi Zhurnal 84(3): 63-71
2012
ISSN/ISBN: 0372-3909 PMID: 22860403 Document Number: 661428
It was shown that development of the Guerin carcinoma and introduction of cisplatin led to the damage of the kidneys of rats that was confirmed by a relative increase of weight, proteinuria, change of gamma-glutamyl transpeptidase and lactate dehydrogenase activity in the urea and tissue homogenates of the kidneys, by a decrease of relative reabsorption and glomerular filtration. Introduction of nanoliposomal forms of the rhenium cluster compounds led to normalization of above mentioned diagnostic indexes and to reduction of the toxic cisplatin influence that was confirmed by biochemical and morphological investigations.