The mechanism of HBV disruption on RIG-i signaling pathway
Yan, L.; Huang, F.; Tang, H.
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 29(5): 995
2012
ISSN/ISBN: 1001-5515 PMID: 23198448 Document Number: 661342
Hepatitis B virus (HBV) infection disrupt the innate immunity response, which may play an important role in the chronic mechanism, while retinoic acid-induced gene I (RIG-I) mediated signaling pathway is one of the most important channel in the innate immunity. HBx and HBV polymerase may disrupt RIG-I mediated signaling pathway. The recent advances about HBV and RIG-I are reviewed in this article.