Study on phenotypical activity of isoenzyme CYP3A4 in children
Kantemirova, B.I.; Chernysheva, A.K.; Starodubtsev, A.K.; Sychev, D.A.
Antibiotiki i Khimioterapiia 57(1-2): 23-25
2012
ISSN/ISBN: 0235-2990 PMID: 22741198 Document Number: 660336
The urine levels of cortisol and 6-beta-hydroxycortisol in 30 healthy children were determined with high performance liquid chromatography. The activity of cytochrome P450 isoenzyme CYP3A4 was estimated by the ratio of 6-beta-hydroxycortisol and cortisol. Differences in the CYP3A4 activity depended on the age sex. At the age of 4 to 9 years the value of the ratio was 9.21 +/- 0.67 which in fact was statistically higher than that in the children at the age of 0 to 3 years (p<0.001). In the female children at the age of 0 to 3 years the value of the isoenzyme CYP3A4 activity was actually lower (p<0,05) vs. the female children of the higher ages and the male children at the age of 0 to 3 years. The results are useful for further researches on improvement of drugs dosing and prevention of adverse reactions.