KPC carbapenemase producing Gram-negative bacteria
Yamane, K.
Nihon Rinsho. Japanese Journal of Clinical Medicine 70(2): 267-271
2012
ISSN/ISBN: 0047-1852 PMID: 22413530 Document Number: 658455
Carbapenem is the last resort for infections due to Gram-negative bacteria. However, carbapenem-resistant Enterobacteriaceae such as KPC-producing bugs were reported in the United States from early this decade and now worldwide. According to the nationwide surveillance study in Japan performed between September and December, 2010, two bla(KPC)-harboring Klebsiella pneumoniae were identified among 153 multi-drug-resistant Enterobacteriaceae. Moreover, 72 out of 153 multi-drug-resistant Enterobacteriaceae harbored bla(IMP-1). The results of this surveillance study demonstrated that the most epidemic carbapenemase in Japan is not bla(KPC) but bla(LMP-1). Although the bla(KPC)-harboring strain is very rare in Japan, detection of KPC-producing Gram-negative bacteria may be difficult based on the CLSI recommended method. Development of effective screening methods is needed in the Japanese healthcare environment.