Regulatory mechanism underlying pathogen biofilm formation and potential drug targets
Shi, T.-Y.; Deng, W.-Y.; Xie, J.-P.
Yao Xue Xue Bao 47(2): 135-143
2012
ISSN/ISBN: 0513-4870 PMID: 22512022 Document Number: 658151
Bacterial communities usually develop biofilms abound in nature niche. The development of biofilm is a highly dynamic and complex process coordinated by multiple mechanisms, of which two-component system and quorum sensing are two well-defined systems. Biofilm is involved in the virulence of many pathogens. Therefore, targeting the key factors involved in the biofilm formation represents a novel and promising avenue for developing better antibiotics.