Meta-analysis of randomized trials of antimicrobial drugs in the treatment of coronary heart disease
Skochko, O.V.; Kaĭdashev, I.P.
Likars'ka Sprava 5: 72-86
2012
ISSN/ISBN: 1019-5297 PMID: 23534274 Document Number: 658005
The meta-analysis of 12 clinical research of application of antibiotics (azithromycin, roxithromycin clarithromycin, gatifloxacin) in 24 949 patients with coronary heart disease were carried out. The obtained results were shown that application of short courses of antibiotic therapy in patients with severe morphological changes in small coronary vessels were not enough effective. Contrariwise, long-term courses of antibiotic therapy could be effective in patients with initial lesions of blood vessels and presence of chronic infections.