Role of estradiol in hypoxia-induced pulmonary hypertension in female rats
Kovaleva, I.O.; Artem'eva, M.M.; Ilatovskaia, M.E.; Medvedev, O.S.; Medvedeva, N.A.
Eksperimental'naia i Klinicheskaia Farmakologiia 75(12): 19-21
2012
ISSN/ISBN: 0869-2092 PMID: 23700662 Document Number: 657841
Gender differences play role in pathogenesis and treatment of many cardiovascular diseases. One of these diseases is hypoxia-induced pulmonary hypertension (PHT). The aim of this study was to analyze the involvement of female hormone estradiol in development of hypoxia-induced PHT in female Wistar rats. PHT was induced by exposure to hypobaric hypoxia in an altitude chamber at a simulated altitude of 5000 m (02 concentration reduced to 10 %), 10 h per day for 2 weeks. The development of PHT leads to a twofold increase in the level of estradiol. Ovariectomy decreases by half the level of estradiol and causes significant decrease in hypoxia-induced PHT symptoms.