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WT1-targeting cancer vaccine

Sugiyama, H.

Nihon Rinsho. Japanese Journal of Clinical Medicine 70(12): 2105-2113

2012

ISSN/ISBN: 0047-1852
PMID: 23259381
Document Number: 657664
Wilms' tumor gene WT1 encodes a transcription factor and functions as an oncogene. WT1 gene product WT1 protein is a promising par-tumor-associated antigen. WT1 peptide-based immunotherapy has been performing for more than six hundred patients with leukemias and various types of solid tumors. This immunotherapy is safe and has clinical benefit especially for leukemia, glioblastoma multiforme, advanced pancreatic cancer, and ovarian cancer. As a new strategy for cancer treatment, it should be recommended to initiate immunotherapy that had a potential of eradication of cancer stem cells before surgery, chemo- and radio-therapy.

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