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Diagnosis and targeting therapy of colorectal cancer using antibody

Yamaguchi, T.; Takahashi, T.; Kitamura, K.; Otsuji, E.; Kotani, T.; Kato, M.; Yata, Y.; Okamoto, K.; Nishi, H.; Ichikawa, D.; Yamamoto, K.

Gan to Kagaku Ryoho. Cancer and ChemoTherapy 23(5): 549-553

1996

ISSN/ISBN: 0385-0684
PMID: 8678511
Document Number: 463401
Application of monoclonal antibody for diagnosis and therapy of colorectal cancer was reviewed. The history and present status of radioimmunoimaging of cancer were presented. Immuno-guided surgery using radiolabeled antibody and hand-aided detector during surgery is a promising approach for complete excision of cancerous region. Also, a new antibody labeling method using a micro-magnet instead of radioisotopes may lead to a new era in immunodiagnosis of cancer. Finally, immunotargeting chemotherapy using antibody-anticancer drug conjugates was reviewed. A new type of immunoconjugate composed of human/mouse chimeric antibody and Neocarzinostatin seems to be one of the most promising drug formulas for immunotargeting chemotherapy.

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