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Photodynamic diagnosis and laser biospectroscopy as an intraoperative guidance in neurosurgery

Goriaĭnov, S.A.; Potapov, A.A.; Gol'bin, D.A.; Zelenkov, P.V.; Kobiakov, G.L.; Gavrilov, A.G.; Okhlopkov, V.A.; Shukhraĭ, V.A.; Shelesko, E.V.; Zhukov, V.I.; Loshchenov, V.B.; Savel'eva, T.A.; Kuz'min

Zhurnal Voprosy Neirokhirurgii Imeni N. N. Burdenko 76(6): 57-65; Discussion 65

2012

ISSN/ISBN: 0042-8817
PMID: 23379185
Document Number: 657427
Different techniques are used today in neurosurgery for intraoperative navigation, including metabolic guidance using 5-aminolevulinic acid (5-ALA). The article focuses on history of intraoperative photodynamic diagnosis (PDD), mechanisms of 5-ALA action, possibilities of its application in different areas of neurosurgery. In addition to visual assessment of fluorescence, laser biospectroscopy significantly increases the diagnostic value of PDD. Laser biospectroanalysis is described in details, wide perspectives of its application in neurosurgery are demonstrated.

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