Early detection of possibilities for preeclampsia using VEGF1 and other serum analysis
Manolov, V.; Marinov, B.; Vasilev, V.
Akusherstvo i Ginekologiia 51(Suppl 1): 33-41
2012
ISSN/ISBN: 0324-0959 PMID: 23236677 Document Number: 657380
The aim of our study is to establish an interaction between serum VEGF1 levels and possibilities of early detection of preeclampsia. For a period of three months we follow up 17 patients with preeclampsia in second trimester by measuring serum levels of VEGF1, PIGF and Inhibin A. A correlation between them was determined. During our study we investigate 17 patients with preeclampsia and 35 as a control group. Significant differences between serum levels in too groups were established. Serum levels for VEGF1 above 158.5 pg/ml; Inhibin A above 98.50 ng/ml; PIGF levels above 30.01 pg/ml shows a diagnostic sensitivity 88.895 and diagnostic specificity 97.06% in prediction of preeclampsia. Measurement of serum VEGF1, PIGF and Inhibin A levels are suitable for early prediction of possibilities for preeclampsia in second trimester. These results are the basis for further studies in this field.