Significance of nuclear magnetic resonance combined with Ki-67 and VEGF detection in the diagnosis and prognosis evaluation of brain glioma
Yuan, X.; Liu, D.; Wang, Y.; Li, X.
Journal of BUON Official Journal of the Balkan Union of Oncology 23(2): 410-415
2018
ISSN/ISBN: 1107-0625 PMID: 29745085 Document Number: 697339
To investigate the significance of nuclear magnetic resonance (NMR) combined with Ki-67 and vascular endothelial growth factor (VEGF) detection in the diagnosis and prognosis evaluation of brain glioma. 78 patients with brain glioma treated at the Affiliated Hospital of Jining Medical University from January 2015 to August 2017 were studied. All patients underwent the NMR diffusion tensor imaging examination. The expressions of Ki-67 and VEGF in brain glioma tissues were detected using immunohistochemistry and survival analyses were performed for patients in high apparent diffusion coefficient (ADC) group and low ADC group, high-expression Ki-67 and VEGF group and low-expression Ki-67 and VEGF group before treatment. Moreover, the value of combined diagnosis in the prognosis evaluation of patients was analyzed. NMR diffusion tensor imaging showed that the fractional anisotropy (FA) value in the tumor enhancement region on the affected side was significantly lower than in the contralateral normal region, but ADC was significantly higher in the contralateral normal region; the FA value in grade I-II brain glioma enhancement region was higher compared with grade III-IV glioma enhancement region, but ADC was lower in the grade-III-IV glioma enhancement region (p<0.05). The low expression rates of Ki-67 and VEGF in patients with grade I-II brain glioma were significantly higher than in patients with grade III-IV glioma (p<0.05). After treatment, the 3-year survival rate of high ADC group was lower than that of low ADC group, and the 3-year survival rate of high-expression Ki-67 and VEGF group was also obviously lower than that in low-expression Ki-67 and VEGF group (p<0.05). Besides, the area under the receiver operating characteristic (ROC) curve of NMR combined with Ki-67 and VEGF detection in the prediction of patient prognosis was 0.906, the sensitivity 91.6%, and the specificity 89.5%. NMR diffusion tensor imaging has a high application value in the diagnosis of brain glioma. The expressions of Ki-67 and VEGF are related to the pathological grade of glioma, which can be used as biological indexes for the diagnosis of glioma. Moreover, the combined detection of the three items can not only accurately determine the grade of glioma malignancy, but also effectively evaluate the prognosis of patients, thus providing a scientific basis for the selection of therapeutic regimen.