Squamous cell carcinoma in mature cystic teratoma of the ovary
Amidzić, J.; Dolai, M.; Kaćanski, M.M.; Gluhović, A.; Ilić, J.; Bozanić, S.
Medicinski Pregled 65(9-10): 429-431
2012
ISSN/ISBN: 0025-8105 PMID: 23214338 Document Number: 657093
Malignant transformation is a rare complication of mature cystic teratoma, with squamous cell carcinoma as the most common malignancy (in 75% of cases). In this article we present a case of a well-differentiated squamous cell carcinoma arising in a mature cystic teratoma and discuss the morphological and clinico-pathological features of malignant transformation in teratoma. An 80-year-old woman with symptoms of acute abdomen underwent left salpingo-oophorectomy. Gross examination showed a cystic mass measuring 20 cm in diameter, with papillary formation on its internal surface. Histology revealed a well-differentiated squamous cell carcinoma arising in mature cystic teratoma. Squamous epithelium surrounding the tumor was dysplastic. Squamous cell carcinoma in mature cystic teratoma is a rare pathologic event and in most cases it is an accidental pathohistological finding.