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Analysis of combination chemotherapy with docetaxel and nedaplatin for esophageal cancer

Kawada, J.; Iwase, K.; Deguchi, K.; Higashi, S.; Deguchi, T.; Matsuda, C.; Tamagawa, H.; Omori, K.; Nishikawa, K.; Nomura, M.; Takagi, M.; Fukui, A.; Tanaka, Y.

Gan to Kagaku Ryoho. Cancer and ChemoTherapy 39(12): 2095-2097

2012

ISSN/ISBN: 0385-0684
PMID: 23267988
Document Number: 656339
There is no standard second line regimen for metastatic or recurrent esophageal cancer. We investigated the feasibility of combination chemotherapy with Docetaxel (DOC) and Nedaplatin (CDGP) as a second-line regimen for metastatic or recurrent esophageal cancer. Patients received DOC (60 mg/m2 intravenously) on day 1 and subsequently CDGP(70 mg/m2 intravenously) on day 1 of each 4-week period thereafter. We analyzed the toxicity and efficacy in 9 patients treated with combination chemotherapy with DOC and CDGP. The observed Grade 3-4 toxicities were neutropenia and anemia. Three patients had stable disease and 6 patients had progressive disease. The median progression free survival and overall survival were 4.3 and 8.1 months, respectively. Combination chemotherapy with DOC and CDGP is considered a feasible second line regimen for metastatic or recurrent esophageal cancer.

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