Analysis of four patients with advanced gastric cancer undergoing gastrectomy after pre-operative combination chemotherapy using docetaxel, cisplatin and S-1
Nagase, T.; Kanai, T.; Nakagawa, M.; Kumamoto, Y.; Imai, S.; Wada, O.; Honda, T.; Hoshino, G.; Atsukawa, K.; Sakaguchi, T.; Shiba, T.; Nonaka, T.; Imajyo, K.; Ogawa, Y.
Gan to Kagaku Ryoho. Cancer and ChemoTherapy 37(11): 2177-2179
2010
ISSN/ISBN: 0385-0684 PMID: 21084822 Document Number: 646460
We analyzed the clinical efficacy of pre-operative combination chemotherapy using docetaxel, cisplatin and S-1 for advanced gastric cancer. Four patients were enrolled and staging laparoscopy was performed. Patients received intravenous docetaxel and cisplatin (35 mg/m2) on day 1 and 15, and oral S-1 80 mg/m2 on day 1-14 every 4 weeks. Two patients received two courses of chemotherapy and two patients received three courses of chemotherapy. Neutropenia of more than grade 3 was found in 3 cases. All cases were PR on preoperative imaging. Curative operation was performed on three cases. Histological anti-tumor effect was judged to be grade 2 in 1 case and grade 1a in 3 cases. In the postoperative period, all patients received S-1-based adjuvant chemotherapy. The combination chemotherapy using docetaxel, cisplatin and S-1 plus operation was a candidate for the standard treatment strategy for advanced gastric cancer.