Anaesthetic and postanaesthetic effect of isoflurane on the multiple-unit activity of the immature rat hippocampus
Isaeva, E.V.; Isaev, D.S.
Fiziolohichnyi Zhurnal 57(1): 17-20
2011
ISSN/ISBN: 2522-9028 PMID: 21513222 Document Number: 655122
We investigated anesthetic and postanaesthetic effect of isoflurane on the multi-unit activity (MUA) in the CA3 region of immature rat hippocampus. MUA amplitude did not significantly change during application of isoflurane. On the other hand MUA frequency significantly decreased during the anesthesia. After isoflurane discontinuation two phases of MUA frequency recovery were observed: initial rapid increase followed by a slower recovery to the control level. Comparison of recovering period of the receptor mediated systems and spontaneous field activity from isoflurane anesthesia is discussed.