State of the endothelium and hemostasis in acute leukemia
Tarasova, L.N.; Skol'skaia, O.I.; Vladimirova, S.G.
Terapevticheskii Arkhiv 83(7): 74-78
2011
ISSN/ISBN: 0040-3660 PMID: 21894757 Document Number: 654168
The review presents modern conceptions of disturbances in endothelial lining of the vessels and plasmic hemostasis in patients with acute leukemia; different mechanisms of coagulation disorders in acute leukemia: effects of leukemic cells containing procoagulants, fibrinolytic and antifibrinolytic substances, of intensive chemotherapy and inflammation. All these impacts impair endothelial cells and trigger plasmic coagulation cascade; the initiator of coagulation is a tissue factor. Mechanisms of this process and statistics of thrombohemorrhagic complications in different variants of acute leukemia are outlined.