Life threatening hyperkalemia chronic kidney diseases patients treated with trimethoprim-sulfamethoxazole: a case series
Calderón-Ortiz, R.; Colton-Verge, P.; Muñiz-Ortega, M.; Lespier, L.; Córdova, H.éc.
Boletin de la Asociacion Medica de Puerto Rico 103(3): 15-17
2011
ISSN/ISBN: 0004-4849 PMID: 23210327 Document Number: 654018
We report a case series of patients that develop severe life threatening hyperkalemia after use of a commonly prescribe oral antibiotic, Trimethoprim-Sulfamethoxazole. The three patients required acute hemodialysis to normalize serum potassium levels after development of hypotension and heart block due to hyperkalemia. All had preexisting chronic kidney disease. Some of them were on medications that interfere with the effects of aldosterone. Patients with chronic kidney disease, particularly those receiving other medications that may also contribute to the development of hyperkalemia, should be closely monitored for this complication when Trimethoprim-containing antibiotic is needed. In these cases, other antibiotic therapy alternatives should be considered.
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