Optimization of topical gels with betamethasone dipropionate: selection of gel forming and optimal cosolvent system
Băiţan, M.; Lionte, M.; Moisuc, Lăcrămioara.; Gafiţanu, E.
Revista Medico-Chirurgicala a Societatii de Medici Si Naturalisti Din Iasi 115(2): 601-605
2011
ISSN/ISBN: 0048-7848 PMID: 21870764 Document Number: 653722
The purpose of these studies was to develop a 0.05% betamethasone gel characterized by physical-chemical stability and good release properties. The preliminary studies were designed to select the gel-forming agents and the excipients compatible with betamethasone dipropionate. In order to formulate a clear gel without particles of drug substances in suspension, a solvent system for the drug substance was selected. The content of drug substance released, the rheological and in vitro release tests were the tools used for the optimal formulation selection. A stable carbomer gel was obtained by solubilization of betamethasone dipropionate in a vehicle composed by 40% PEG 400, 10% ethanol and 5% Transcutol.